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In page House of Medici:

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After securing Alessandro de' Medici's dukedom, Pope Clement VII married off his first cousin, twice removed, Catherine de' Medici, to the son of Emperor Charles V's arch-enemy, King Francis I of France—the future King Henry II. This led to the transfer of Medici blood, through Catherine's daughters, to the royal family of Spain through Elisabeth of Valois, and the House of Lorraine through Claude of Valois.[citation needed]