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In page Tick:

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Topical tick medicines may be toxic to animals and humans. The synthetic pyrethroid insecticide phenothrin in combination with the hormone analogue methoprene was a popular topical flea and tick therapy for felines. Phenothrin kills adult ticks, while methoprene kills eggs. Some cat products were withdrawn in the US due to adverse reactions,[9] and others are known to cause adverse reactions.[citation needed]