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In page Chemotherapy:

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Isolated limb perfusion (often used in melanoma),[4] or isolated infusion of chemotherapy into the liver[5] or the lung have been used to treat some tumors. The main purpose of these approaches is to deliver a very high dose of chemotherapy to tumor sites without causing overwhelming systemic damage.[6] These approaches can help control solitary or limited metastases, but they are by definition not systemic, and, therefore, do not treat distributed metastases or micrometastases.[citation needed]