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In page Mycoplasma genitalium:

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Owing to the widespread macrolide resistance, samples that are positive for Mgen should ideally be followed up with an assay capable of detecting mutations that mediate antimicrobial resistance. The European Guideline on Mgen infections, in 2016,[1] recommended complementing the molecular detection of Mgen with an assay capable of detecting macrolide resistance-associated mutations.[citation needed]