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In page Johann Friedrich Struensee:

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First he reconciled the king and queen. At first Caroline Matilda disliked Struensee, but she was unhappy in her marriage, neglected and spurned by the king, and affected by his illness. However, Struensee was one of the few people who paid attention to the lonely queen, and he seemed to do his best to alleviate her troubles.[citation needed] Over time her affection for the young doctor grew and by spring 1770 he became her lover; a successful vaccination of the baby crown prince in May still further increased his influence.[1]